Obstructive Sleep Apnea Trials

AMAZE 3 (enrolling)

AMAE 4 (closed for enrollment)

(Obstructive Sleep Apnea + Obesity)

Tired of your obstructive sleep apnea symptoms ?

The AMAZE studies are researching an investigational medication for adults with obstructive sleep apnea (OSA) who are also living with overweight or obesity.

OSA occurs when the airway becomes blocked during sleep, leading to:

  • Loud snoring

  • Interrupted breathing

  • Daytime fatigue and low energy

This study is evaluating whether a medication that targets weight and metabolic pathways may help:

  • Reduce the severity of sleep apnea

  • Improve breathing during sleep

  • Support meaningful weight loss

You may qualify if you:

  • Have been diagnosed with obstructive sleep apnea

  • Have a BMI ≥27

  • Participants need to have attempted PAP therapy but currently not tolerate nor use any treatment (unfortunately, those currently on PAP therapy are no longer able to be screened as the recruitment has ended)

What makes this study different:

  • Investigational medication aimed at the root cause of OSA (weight-related airway obstruction)

  • Potential alternative to CPAP

Participants receive:

  • Study-related care at no cost

  • Counsel by a dietician 

  • Sleep evaluations and health monitoring

  • Compensation for your time and travel

Interested? Email us at research@tricoastalsleep.com or click here.